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About tirzepatide
Tirzepatide is a weekly injectable developed by Eli Lilly. It targets both GLP-1 and GIP receptors — the dual mechanism sets it apart from semaglutide (Ozempic, Wegovy), which only hits GLP-1. In the SURMOUNT-1 trial, the 15 mg dose produced 22.5% average body weight loss over 72 weeks. That's the highest average weight loss ever recorded in an obesity drug trial as of 2026.
It's available as Mounjaro (diabetes) and Zepbound (obesity). A licensed provider must evaluate you before prescribing either version. Most clinics offer an initial consultation as part of starting the program.
Frequently asked questions
What is tirzepatide?
Tirzepatide is a weekly injectable medication made by Eli Lilly. It's sold as Mounjaro for type 2 diabetes and Zepbound for obesity. Unlike semaglutide (Ozempic, Wegovy), which targets one hormone receptor (GLP-1), tirzepatide targets two — GLP-1 and GIP. That dual mechanism is why it produces greater average weight loss than semaglutide in head-to-head data.
How much weight can you lose on tirzepatide?
In the SURMOUNT-1 trial (Jastreboff et al., NEJM 2022), participants taking the highest dose of tirzepatide (15 mg/week) lost an average of 22.5% of body weight over 72 weeks. That's roughly 50 lbs for a 220-lb person. Lower doses (5 mg, 10 mg) produced 15% and 19.5% average losses respectively. Individual results vary based on starting weight, diet, and adherence.
What is the difference between Mounjaro and Zepbound?
Same drug, same doses, different FDA approvals. Mounjaro is approved for type 2 diabetes. Zepbound is approved for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with a weight-related condition. Zepbound was approved in November 2023. Insurance coverage for weight loss is available through Zepbound; Mounjaro used off-label for weight loss is rarely covered.
How much does tirzepatide cost per month?
Zepbound lists at approximately $1,060/month without insurance. Mounjaro lists at $1,000–$1,200/month. Eli Lilly offers a savings card that can reduce Zepbound costs significantly for eligible commercially insured patients. Some compounding pharmacies were producing tirzepatide during a shortage period, but that legal landscape has shifted — check with your clinic about current availability.
Does insurance cover tirzepatide (Zepbound)?
Increasingly, yes. More commercial insurance plans have added Zepbound coverage since its 2023 approval compared to Wegovy. Prior authorization is standard. Coverage for Mounjaro used off-label for weight loss remains rare. Medicare coverage for Zepbound is limited; it covers Mounjaro for qualifying diabetes patients.
Who qualifies for tirzepatide?
For Zepbound (weight management): adults with a BMI of 30+ (obesity) or 27+ (overweight) with at least one weight-related condition like hypertension, type 2 diabetes, dyslipidemia, or obstructive sleep apnea. A licensed provider must evaluate you before prescribing. Most in-person clinics listed on GLPFinders include a consultation as part of their process.
What are the side effects of tirzepatide?
Mainly GI: nausea, diarrhea, vomiting, constipation. Most pronounced when starting or increasing the dose, typically improving over time. In the SURMOUNT-1 trial, 31–43% of tirzepatide patients reported nausea versus 14% on placebo. Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or MEN 2.
Is tirzepatide better than semaglutide?
By average weight loss numbers, yes — 22.5% for tirzepatide 15 mg vs ~14.9% for semaglutide 2.4 mg in their respective trials. But these were different trials with different populations, so direct comparison isn't perfect. A head-to-head trial (SURPASS-CVOT vs STEP outcomes) showed tirzepatide outperforming semaglutide on weight endpoints. Whether that translates to better results for any individual patient depends on their response and tolerance.
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